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Letters in Organic Chemistry

Author(s): Laila Baddi, Michael Smietana, Said Sebti, Jean-Jacques Vasseur and Hassan B. Lazrek

DOI: 10.2174/157017810791112441

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A Procedure for Facile Synthesis of Nucleosides Using N, O-Bistrimethylsilylacetamide in the Presence of Natural Phosphate Coated with Potassium Iodide

Page: [196 - 199] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

Several α-D/L-arabino and β-D/L- xylonucleosides were synthesized in good yields under mild conditions by N-glycosylation of 1-O-acetyl D/L- arabino, and xylofuranose, with silylated nucleobases (uracil, thymine and 6- azauracil) in acetonitrile using natural phosphate (NP) coated with potassium iodide in BSA as catalyst.

Keywords: N-Glycosylation, D/L nucleosides, natural phosphate, catalyst