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Letters in Organic Chemistry

Author(s): Gustavo H.G. Trossini, Jeanine Giarolla, Leandro de Rezende, Antonia T. do Amaral, Marcio H. Zaim, Roy E. Bruns and Elizabeth I. Ferreira

DOI: 10.2174/157017810791112513

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Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 32 Factorial Design

Page: [191 - 195] Pages: 5

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Abstract

Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 32 factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K2CO3) ratio.

Keywords: Factorial design, synthesis optimization, hydroxymethylnitrofurazone (NFOH), antichagasic candidate, response surface methodology