Drastic Effects on Fibril Formation of Amyloid-β Peptides by the Addition of Amino Acid Residue Units to the Termini

Yuya      Asanomi; Yumiko      Kobayashi; Hiroki      Sakai; Takuya      Masuda; Xinjiang      Chen; Yoshiro      Chuman; Kohei      Uosaki; Kazuyasu      Sakaguchi

Protein & Peptide Letters

Author(s): Yuya Asanomi, Yumiko Kobayashi, Hiroki Sakai, Takuya Masuda, Xinjiang Chen, Yoshiro Chuman, Kohei Uosaki and Kazuyasu Sakaguchi

DOI: 10.2174/092986610790963618

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Drastic Effects on Fibril Formation of Amyloid-β Peptides by the Addition of Amino Acid Residue Units to the Termini

Page: [458 - 463] Pages: 6

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Abstract

We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Aβ(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.

Keywords: Aβ, amyloid, atomic force microscopy, bionanomaterial, fibril formation, self-assembly

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