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Letters in Organic Chemistry

Author(s): Josefina Pons, Arafa Chadghan, Jordi Garcia-Anton and Josep Ros

DOI: 10.2174/157017810790796273

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Phenyl and Pyridyl Bis-Pyrazoles: Synthesis from the Bis(β-diketone) Precursors and Characterization by Analytical and Spectroscopic Methods

Page: [178 - 181] Pages: 4

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Abstract

The bis(β-diketone) compounds, 3,3-(pyridine-2,6-diyl)bis(1-phenylpropane-1,3-dione) monohydrated (1a H2O) and 3,3-(pyridine-2,6-diyl)bis(1-(pyridin-2-yl)propane-1,3-dione) monohydrated (1b H2O) were prepared by Claisen condensation of the appropriate ketone and dimethyl pyridine-2,6-dicarboxylate ester. Compounds 2,6-bis(5- phenyl-1H-pyrazol-3-yl)pyridine dihydrated (2a 2H2O) and 2,6-bis(5-(pyridin-2-yl)-1H-pyrazol-3-yl)pyridine monohydrated (2b H2O) were synthesized by reaction of the appropriate bis(β-diketone) compounds and hydrazine monohydrate.

Keywords: Nitrogen heterocycles, bis-pyrazole, bis(β-diketone), NMR spectroscopy