Abstract

In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

Keywords: Tartaric acid, malic acid, thiadiazole, acylation, nucleophilic substitution, matrix metalloproteinase inhibitors