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Protein & Peptide Letters

Author(s): Zhuo-Ran Huang, Tong-Yang Zhu, Ting-Ting Wang, Xiao-Ning Wang and Jie Yang

DOI: 10.2174/092986610790780369

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Molecular Dynamics of Some Pentapeptides Having a Strong Tendency to Helical Conformation

Page: [367 - 380] Pages: 14

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Abstract

Some pentapeptides with higher alpha-helical tendency possess typical sequence pattern, such as “+ - + + - - +”, “+ - - + - - +”, “+ - + - - - +”, and “- + + - - - +” (“+” = D,N,E,Q,K,R,T,C, or H; “-” = L,I,V, or A), especially symmetrical motifs (a pair of reverse sequences beside palindromic segments), such as ALALA, QQAQE/EQAQQ, and REALE/ELAER, hint that the nascent peptide can fold a certain conformation in a two-way folding fashion.

Keywords: Folding models, symmetrical motifs, molecular dynamics