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Protein & Peptide Letters

Author(s): Ricardo F. Lima, David N. Criddle, Pedro Marcos G. Soares, Samile Pereira Ribeiro, Benildo S. Cavada, Kyria S. Nascimento, Alexandre H. Sampaio and Ana Maria S. Assreuy

DOI: 10.2174/092986610790780332

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Bryothamnion seaforthii Lectin Relaxes Vascular Smooth Muscle: Involvement of Endothelium and NO Synthase

Page: [305 - 310] Pages: 6

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Abstract

Bryothamnion seaforthii lectin (BSL) induced reversible concentration-related relaxation of endothelized aorta, maximal at 30μg/ml (IC50= 4.8 ± 0.6μg/ml). This effect was inhibited by L-NAME and reversed by mucin, probably via interaction with a specific lectin-binding site on the endothelium activating nitric oxide synthase.

Keywords: Lectin, agglutinin, Bryothamnion seaforthii, nitric oxide synthase, red marine alga