Protein & Peptide Letters

Author(s): A. A. Moosavi-Movahedi, H. Sepassi Tehrani, M. Amanlou, M. N. Soltani Rad, G. H. Hakimelahi, F. Y. Tsai, A. A. Saboury, F. Ahmad, A. Khalafi-Nezhad, N. Poursasan and A. Sharifizadeh

DOI: 10.2174/092986610790226076

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Kinetic and Conformational Studies of Adenosine Deaminase Upon Interaction with Oxazepam and Lorazepam

Page: [197 - 205] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Oxazepam and lorazepam inhibit the adenosine deaminase (ADA) differently. In the case of lorazepam temperature increment causes an increase in the inhibition potency whereas higher temperature reduces the inhibitory effect of oxazepam; which proposes the overall profounder structural changes in the case of lorazepam relative to those caused by oxazepam.

Keywords: Adenosine deaminase, oxazepam, lorazepam, kinetics, structures