Abstract

Laminin-332 and α6β4 integrin is major hemidesmosome components in the skin. As many studies have shown that laminin-332 and α6β4 integrin play important roles in tumor progression via activation of phosphatidylinositol-3 kinase signaling, understanding of the molecular mechanisms of them could lead to a new drug for cancer therapy.

Keywords: Laminin-332, α6β4 integrin, basement membrane, extracellular matrix, tumor, cell migration, cell adhesion, ErbB2