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Letters in Organic Chemistry

Author(s): Kuladip Sarma and Amrit Goswami

DOI: 10.2174/157017809789869456

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An Efficient Method for One-Pot Reductive Cleavage of Acetals to Primary Alcohols Using a Bimetal Redox Couple CoCl2.6H2O-Zn

Page: [568 - 572] Pages: 5

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Abstract

Acyclic or cyclic O,O-acetals and O,S-acetals underwent reductive cleavage to give primary alcohols efficiently on treatment with Zn-CoCl2.6H2O-bimetal redox system in dry tetrahydrofuran at ambient temperature to give good to excellent yields.

Keywords: Alcohols, acetals, bimetal redox system, deprotection, hydroxy ether, reductive cleavage