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Protein & Peptide Letters

Author(s): Qing-Shan Fu, Ai-Xin Song, Su-Xia Li and Hong-Yu Hu

DOI: 10.2174/092986609789839386

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The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Page: [1442 - 1446] Pages: 5

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Abstract

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities.

Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease