Abstract

A specific SPRI sensor for cathepsin determination based on the interaction between immobilized cystatin and cathepsins has been developed. All cathepsins form the same calibration curve. The sensor dynamic response range is between 0.5 and 2.0 ng ml-1 and the detection limit is equal to 0.1 ng ml-1.

Keywords: Surface Plasmon Resonance Imaging, cathepsins, cystatin, biosensor, blood plasma, leukocytes