Abstract

Since there are not much experimental data available about different structural properties of Isfahan virus (ISFV), in the present investigation, computational study of G protein of ISFV was performed and the results were compared with G proteins of Chandipura virus (CHPV) and Piry virus (PV). Calculation of amino acid compositions of G proteins of viruses was done by PseAAC server. Predictions of localization, sequence of signal peptides, C, N and O glycosylation sites, transmembrane helices, cysteine bond positions and B cell epitopes of G proteins were performed by Virus- PLoc, Signal-CF, EnsembleGly, MemBrain, DiANNA and BCPREDS servers respectively. Similarities and differences between these glycoproteins were predicted and discussed.

Keywords: Isfahan virus, Chandipura virus, Piry virus, Bioinformatics