Abstract

Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.

Keywords: TAFI, carboxypeptidase B, carboxypeptidase U, carboxypeptidase R, fibrinolysis, inflammation