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Protein & Peptide Letters

Author(s): A.H.C. de Oliveira, E. A. Aragao, J. M. Sa, L. Chioato, R. Bugs-Bortoleto, R. Ruller, T. L. Ferreira and R. J. Ward

DOI: 10.2174/092986609788923392

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Calcium-Independent Membrane Damage by Venom Phospholipases A2

Page: [877 - 886] Pages: 10

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Abstract

Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.

Keywords: Membrane permeabilization, molecular mechanism, micelle nucleation