Author(s): A. Hanna-Elias, P. E. Thompson, D. T. Manallack, H. R. Irving, I. M. Coupar, I. Berque-Bestel and M. N. Iskander
Page: [805 - 809] Pages: 5
* (Excluding Mailing and Handling)
A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.
Keywords: Serotonin, 5-HT, 5-HT4, tripeptide, molecular docking, radioligand binding
Download PDF Flyer