Human villous trophoblast differentiation is a complex and highly regulated process essential for the well-being of the pregnancy and fetal development. In this review, we present an overview of the role of MAPKs signalling in morphological and functional differentiation of villous trophoblast.
Keywords: Human placenta, villous cytotrophoblast, differentiation, mitogen-activated protein kinases, cell signalling, syncytiotrophoblast, peroxisome proliferator-activated receptors, Src family kinase, drug