Author(s): Eunyi Jeon and Jun-Hyeog Jang
Page: [664 - 667] Pages: 4
* (Excluding Mailing and Handling)
The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.
Keywords: Bone, fibroblast growth factor 2, fusion, hydroxyapatite, osteocalcin
Download PDF Flyer