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Protein & Peptide Letters

Author(s): Leila Hasani, Bijan Ranjbar, Mahmood Tavallaie and Majid Sadeghizadeh

DOI: 10.2174/092986609788490131

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Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain

Page: [660 - 663] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

C-terminal fragment of the Botulinum neurotoxin A comprises two sub-domains including HC-N and HC-C. Here, the conformational change of HC-N was studied by spectroscopic techniques. The results indicated that the partially unfolded state forms during unfolding of HC-N. This finding may shed light on poorly – known features of the protein.

Keywords: H, -N, botulinum neurotoxin A, circular dichroism, fluorescence spectroscopy, molten globule like state