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Letters in Organic Chemistry

Author(s): Dina Scarpi, Ernesto G. Occhiato, Antonio Guarna and Valerio Borzatta

DOI: 10.2174/157017810791130667

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One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate

Page: [311 - 313] Pages: 3

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Abstract

A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.

Keywords: Pictet-Spengler, esterification, isomerization, Tadalafil