Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential

Mei-yu      Hu; Chi-tat      Lam; Kang-da      Liu; Zhi      Xu; Sarwat      Fatima; Yvonne   C.F   Su; Felice      Tsang; Jie      Chen; Jin-zhong      Pang; Lun-xiu      Qin; J.   M.   Luk

Protein & Peptide Letters

Author(s): Mei-yu Hu, Chi-tat Lam, Kang-da Liu, Zhi Xu, Sarwat Fatima, Yvonne C.F Su, Felice Tsang, Jie Chen, Jin-zhong Pang, Lun-xiu Qin and J. M. Luk

DOI: 10.2174/092986609788167743

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Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential

Page: [479 - 485] Pages: 7

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Abstract

A monoclonal antibody, McAb9E (IgG3), was generated against a metastatic HCC cell line, MHCC-1. The antigen was characterized as human Caveolin-1 (Cav-1, 21kDa), with pI of 5.65. The Cav-1 antigen was found significantly over expressed in metastatic HCC cell lines as well as in tumor specimens. The Cav-1 specific McAb may be a useful molecular agent for metastatic HCC.

Keywords: Hepatocellular carcinoma, caveolin-1, monoclonal antibody, metastasis

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