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Current Pediatric Reviews

Author(s): Gianfranco Maffei, Vincenzo Manuppelli and Rosario Magaldi

DOI: 10.2174/157339609788185767

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Neonatal Persistent Pulmonary Hypertension Associated with Congenital Cystic Adenomatoid Malformation Treated with Sildenafil: Case Report

Page: [85 - 88] Pages: 4

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Abstract

We report a case with severe persistent pulmonary hypertension (PPHN) associated with congenital cystic adenomatoid malformation of the lung (CCAM) treated with sildenafil PO. The case was unresponsive to the High-Frequency Oscillatory Ventilation (HFOV), with a oxygenation index (OI) of 50 before sildenafil. Substantial improvement in OI was followed by extubation and survival. No side-effects were noted.

Keywords: PPHN, CCAM, sildenafil, HFOV, oxygenation index