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Protein & Peptide Letters

Author(s): Stanislav G. Bayryamov, Nikolay G. Vassilev, Miroslav A. Rangelov, Aneta P. Mladjova and Dimiter D. Petkov

DOI: 10.2174/092986609787848009

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Design and Synthesis of Substrates for Model Ribosomal Reactions

Page: [392 - 401] Pages: 10

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Abstract

2/3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-Ado (1) and its deoxy analog: 3-O-[Bz(NO2)-Orn(Boc)]-5-O-Piv-2- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.

Keywords: Design, peptide synthesis, nucleoside synthesis, ribosome catalysis