Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors

Takahiro      Nishimaru; Yoshihiro      Yamaguchi; Tateaki      Wakamiya

Protein & Peptide Letters

Author(s): Takahiro Nishimaru, Yoshihiro Yamaguchi and Tateaki Wakamiya

DOI: 10.2174/092986609787601787

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Syntheses of NPTX-594 Analogs with Thiol-Containing Fluorophores to Develop a Probe for Analysis of Binding Mode Between Spider Toxins and Glutamate Receptors

Page: [285 - 288] Pages: 4

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Abstract

NPTX-594 is a neurotoxic acylpolyamine isolated from a Madagascar Joro spider and acts as a specific blocker of glutamate receptors (GluRs). The present study reports the creation of novel NPTX-594 analogs with thiol-containing fluorophores for use as visualization probes for the analysis of the binding mode between spider toxins and GluRs, together with the result of their cricket bioassay.

Keywords: Spider toxin, NPTX-594, glutamate receptor (GluR), thiol-containing fluorophore, fluorescent label, cricket bioassay

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