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Letters in Organic Chemistry

Author(s): Ather Farooq Khan, Michael Schnurch, Marko D. Mihovilovic and Peter Stanetty

DOI: 10.2174/157017809787582780

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Halogen Dance and Sequential Cross-Coupling on 2-Anilinothiazoles

Page: [171 - 174] Pages: 4

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Abstract

A series of 4-bromo-5-halo and 4-bromo-5-organometal-2-anilinothiazole derivatives were prepared via the halogen dance (HD) reaction. Subsequent Pd-catalyzed Stille and Suzuki-Miyaura cross-coupling reactions were performed in a sequential manner to obtain novel 4,5-diarylated-2-anilinothiazoles.

Keywords: Pd-catalysis, cross-couplings, thiazole, halogen dance, sequential cross-couplings