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Letters in Organic Chemistry

Author(s): Shouxin Liu, Debin Ji, Yihua Yang, Xiaoli Zhen, Xia Tian and Jianrong Han

DOI: 10.2174/157017809787582744

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A Practical Procedure for Efficient Synthesis of α-Amino Acids

Page: [156 - 158] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

An effective method to prepare racemic α-amino acids was developed. The key reactions involve nitrosation of malonate under basic conditions and reduction of α-hydroxyimino ester derivatives with zinc powder in the presence of acetic anhydride.

Keywords: α-Amino acid, malonate, α-hydroxyimino ester