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Letters in Organic Chemistry

Author(s): Anilkumar R. Kore and Muthian Shanmugasundaram

DOI: 10.2174/157017809787582852

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Design and Synthesis of New Cap Analogs Containing 2-OH Modifications on Both Guanosine and m7Guanosine Moieties

Page: [141 - 144] Pages: 4

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Abstract

Synthesis of new cap analogs containing 2-OH modifications on both guanosine and m7guanosine moieties such as m2 7,2OG[5]ppp[5]m2OG and 2-OH modifications on both m7guanosine moieties such as m2 7,2OG[5]ppp[5] m2 7,2OG are reported. Structures were confirmed by 1H and 31P NMR and mass spectral data.

Keywords: Guanosine, phosphorylation, methylation, modified cap analogs