Mini-Reviews in Medicinal Chemistry

Author(s): H. Yamane, D. M. Denbow and M. Furuse

DOI: 10.2174/1389557510909030300

Screening of Dipeptides Having Central Functions for Excitation and Sedation

Page: [300 - 305] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

The naturally-occurring dipeptide carnosine (β-alanyl-L-histidine) and the tripeptide glutathione (L-γglutamyl- L-cysteinylglycine) are found extensively in animal tissues such as brain and skeletal muscle. Central functions for excitation and sedation of them and their derivatives were screened.

Keywords: Dipeptides, carnosine, glutathione, excitation, sedation