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Mini-Reviews in Medicinal Chemistry

Author(s): Aina Westrheim Ravna and Georg Sager

DOI: 10.2174/138955709787316065

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Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance

Page: [186 - 193] Pages: 8

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Abstract

Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.

Keywords: Molecular modeling, P-glycoprotein/ABCB1, MRP4/ABCC4, MRP5/ABCC5, multidrug resistance