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Protein & Peptide Letters

Author(s): Noriyuki Shiraishi, Yoko Inai and Yoshito Ihara

DOI: 10.2174/092986609787049475

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Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells

Page: [91 - 96] Pages: 6

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Abstract

Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur.

Keywords: Prion protein, PrP-(23-98), aggregates, cytotoxicity, apoptosis, PrP-deficient cell line