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Protein & Peptide Letters

Author(s): Jeerang Wongtraku, Jantana Wongsantichon, Ardcharaporn Vararattanavech, Posri Leelapat, La-aied Prapanthadara and Albert J. Ketterman

DOI: 10.2174/092986609787049367

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Molecular Cloning and Expression of Several New Anopheles cracens Epsilon Class Glutathione Transferases

Page: [75 - 81] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Glutathione transferases, GSTs, are detoxification proteins that are found in most organisms. The acGSTE3-3 had the ability to conjugate 4-hydroxynonenal, a cytotoxic lipid peroxidation product. Although other Epsilon GSTs showed roles in insecticide metabolism, the acGSTE3-3 appeared to have a major role in detoxifying lipid peroxidation products conferring protection against oxidative damage.

Keywords: Glutathione transferase, An. cracens, Epsilon class, 4-HNE, lipid peroxidation, oxidative stress