Abstract

A new solid-phase synthesis of pyrrolizidine nucleus related to hyacinthacine core using L-proline as the starting material is reported. The final step is a new approach with a cyclization-cleave strategy, which releases the product from the resin in good yields under Baylis-Hillman conditions.

Keywords: Hyacinthacine core, solid-phase organic synthesis, L-Proline, enaminoester, Baylis-Hillman reaction