Abstract

In this paper the physiological role of NO and isoforms of NOS in the gastrointestinal tract and the involvement of NO in pathological processes of digestive tract as well as the perspective of therapeutic use of NO-donating drugs and selective inhibitors of phosphodiesterase in the treatment of gastric diseases were presented.

Keywords: Nitric oxide, constitutive nitric oxide synthase, inducible nitric oxide synthase, gastrointestinal tract, inflammatory process, malignant transformations, NO-donor drugs, phosphodiesterase inhibitors