Abstract

Dysregulation of apoptosis is a major contributor to the initiation and aggravation of liver injury. Agents that modulate apoptosis may be of therapeutic benefit in a number of liver diseases, and research related to cell type-specific activation or inhibition of apoptotic signaling pathways will provide new strategies for treatment.

Keywords: Liver, hepatitis, alcohol, hepatocarcinoma, cholestasis, fulminant hepatic failure, steatohepatitis, fibrosis