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Letters in Organic Chemistry

Author(s): Thiago S. Torres, William P. de Macedo, Leandro F. Pedrosa, Maria Cecilia B. V. de Souza, Vitor F. Ferreira, Anna Claudia Cunha, Tamara Fogel, Fernanda da C. Santos, Isakelly P. Marques, Izabel Cristina de P. Paixao and Marcos C. de Souza

DOI: 10.2174/157017808786857615

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Synthesis and Anti-HSV-1 In Vitro Activity of New Phosphoramidates with 4-oxoquinoline and Phtalimidic Nuclei

Page: [644 - 650] Pages: 7

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Abstract

Aminoalkyl phosphoramidates were obtained by either direct phosphorylation of symmetric diamines or a three steps method analogue to Gabriels synthesis and coupled to a 4-oxoquinoline acyclonucleoside, in order to synthesize 4- oxoquinolone phosphoramidates. Two unpublished compounds demonstrated low cytotoxity in comparison to Acyclovir and good HSV-1 cytophatic effects on Acyclovir resistant strains.

Keywords: Aminoalkyl phosphoramidates, 4-oxoquinoline acyclonucleoside, nucleotide analogues, Herpes Simplex Virus type 1 (HSV-1)