Abstract

Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.

Keywords: Cyclopeptide, glycocluster, multivalency, carbohydrate, solid-phase synthesis, oxime ligation