Mini-Reviews in Medicinal Chemistry

Author(s): Ines Mancini, Graziano Guella and Andrea Defant

DOI: 10.2174/138955708786141007

Synthesis of Marine Natural Products with Antimalarial Activity

Page: [1265 - 1284] Pages: 20

  • * (Excluding Mailing and Handling)

Abstract

The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structureactivity relationship (SAR) studies and their mechanism of action.

Keywords: Natural products, marine metabolites, drug discovery, synthesis, retrosynthetic analysis, antiprotozoal, antimalarial, antiplasmodial