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Letters in Organic Chemistry

Author(s): Ruchun Yang, Haixin Ding, Yang Song, Weihong Xiao, Qiang Xiao and Jun Wu

DOI: 10.2174/157017808785982185

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Synthesis of 5-(Carbohydrate-ethynyl)-2-deoxyuridine Derivatives

Page: [518 - 521] Pages: 4

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Abstract

Sonogashira reaction has been successfully applied to the synthesis of a series of 5-(carbohydrate-ethynyl)-2- deoxyuridines for the first time. The synthetic route is general, high-yielding and compatible with the readily removable protecting group.

Keywords: Sonogashira reaction, 5-iodo-2'-deoxyuridine, 2-propynyl β-D-glycosides, nucleosides derivatives, Palladium catalysis, cross coupling reaction