Author(s): Mei Xiao, Hongsong Yang, Suzane M. Klein, Christian M. Muenyi, William L. Stone and Yu L. Jiang
Page: [510 - 513] Pages: 4
* (Excluding Mailing and Handling)
A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.
Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer
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