Author(s): Jin-Seong Park, Kyoung Rak Kim, Hye Young Nam, Chang-Eun Yeom, Chieyeon Chough, Soon Ho Kwon, Seonggu Ro, Dong-Kyu Shin and B. Moon Kim
Page: [980 - 984] Pages: 5
* (Excluding Mailing and Handling)
An efficient asymmetric synthesis of 6-aminobicyclo[2.2.1]heptane-2-carboxylic acid as a novel γ-turn mimic has been achieved. Structural analysis of the γ-amino acid derivative was carried out using 1H NMR spectroscopy and intramolecular hydrogen bonding between side chain amides confirmed the turn structure, which had been predicted by Ab initio computational study.
Keywords: γ-Turn, conformationally constrained, peptidomimetic, enantioselective Diels-Alder, iodolactamization, conformational analysis
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