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Protein & Peptide Letters

Author(s): T. Hianik, A. Porfireva, I. Grman and G. Evtugyn

DOI: 10.2174/092986608785203656

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Aptabodies – New Type of Artificial Receptors for Detection Proteins

Page: [799 - 805] Pages: 7

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Abstract

We report on a new type of artificial receptor formed by hybridization of two DNA aptamers for human thrombin (aptabody). This aptasensor based on multiwalled carbon nanotubes allowed us to detect thrombin with detection limit of 0.3 nM, which was 3 times better in comparison with conventional aptamer.

Keywords: DNA aptamers, Hybridization, Human thrombin, Multiwalled carbon nanotubes, Biosensor, Electrochemical quartz crystal microbalance