Letters in Organic Chemistry

Author(s): Anupam Nayak, Asima Chatterjee, Julie Banerji, Munmun Saha, Sukumar Manna, Sanchayita Kanrar and Tomoyasu Hirose

DOI: 10.2174/157017808784872070

Electrophilic Substitution Reaction of Indole: Part XXII-Synthesis of a Novel Spiro Heterocyclic System

Page: [403 - 406] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

The reaction of indole with acetone in the presence of mineral/Lewis acid continues to be a fascinating area for investigation since 1913, specially due to the instability of the indolyl carbinol being generated in situ. We report here the synthesis of a novel spiro heterocyclic system obtained during the study of this reaction using BF3.Et2O.

Keywords: Indole, acetone, spiro system, X-ray crystallography