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Letters in Organic Chemistry

Author(s): Yongguang Gao, Xinsheng Li, Weiyi Chen and Dongcheng Xu

DOI: 10.2174/157017808784872179

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Palladium-Catalyzed Asymmetric Allylic Substitution Using Phosphoramidite Ligands Bearing 1,1-Binaphthyl Skeleton

Page: [346 - 348] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

A series of chiral phosphoramidite ligands with 1,1-binaphthyl skeleton have been used in palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylallyl acetate, which afford substituted products in excellent yields (up to 100 %) and good enantiometric excesses (up to 83 % ee).

Keywords: Asymmetric synthesis, allylic alkylation, phosphoramidite, palladium, catalyst, complex