Abstract

Catalyzed by the novel pyrrolidine-thiourea bifunctional catalysts with two chiral centers, the asymmetric Michael addition of nitroolefins and cyclohexanones was successfully performed. A wide range of the products were obtained in good to excellent enantioselectivies and diastereoselectivities.

Keywords: Asymmetric catalysis, Michael addition, asymmetric synthesis, pyrrolidine-thiourea bifunctional catalyst, nitroolefin, cyclohexanone