Mini-Reviews in Medicinal Chemistry

Author(s): Florian M.E. Wagenlehner, Christine Wagenlehner, Kurt G. Naber and W. Weidner

DOI: 10.2174/138955708784912210

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Current Anti-Infective Treatment of Bacterial Urinary Tract Infections

Page: [790 - 795] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

Antibiotic resistance nowadays plays an important role in the treatment of uncomplicated and complicated urinary tract infections (UTIs). In uncomplicated UTI efforts are made to use antibiotic substances exclusively for this indication. In complicated UTI substances with activity against bacteria harbouring common resistance mechanisms are investigated. Additionally pharmacokinetic/ pharmacodynamic parameters are used to improve dosing strategies.

Keywords: Urinary tract infections, uncomplicated UTI, complicated UTI, antibiotic resistance, pharmacokinetics, pharmacodynamics