Abstract

The purine ring system is undoubtedly among the most ubiquitous of all the heterocyclic compounds. In recent years modified purine structures both of natural and synthetic origin have been a rich source of biologically active materials. The halogen at 6 position of the purine moiety of the (RS)-9 or 7-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-9H-or 7Hpurines shows an interesting reactivity which is presented and discussed. The anticarcinogenic potential of the target molecules is reported against the MCF-7 cancer cell line.

Keywords: Amination, antitumour compounds, benzodioxepins, purines, suzuki reaction, trifluoromethylation reaction