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Mini-Reviews in Medicinal Chemistry

Author(s): Chris Braumann, Judith Tangermann, Christoph A. Jacobi, Joachim M. Muller and Wolfgang Dubiel

DOI: 10.2174/138955708784223549

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Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets

Page: [421 - 428] Pages: 8

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Abstract

Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.

Keywords: Angiogenesis, tumor, COP9 signalosome, curcumin, emodin, taurolidine