Abstract

A series of β-aminosulfones were synthesized with high enantioselectivities via a new approach, which combines asymmetric hydrogenation of β-ketosulfones and Mitsunobu amination reaction of the corresponding β- hydroxysulfones with a significant high control of the stereochemistry.

Keywords: Catalysts, ruthenium, asymmetric hydrogenation, β-hydroxysulfones, Mitsunobu amination, β-aminosulfones