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Letters in Organic Chemistry

Author(s): Fan Yang, Lixin Wang, Xianguo Li, Jianfen Shen, Jiyu Wang and Xiaoqi Yu

DOI: 10.2174/157017808783955826

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Improved Preparation of Nabumetone by Raney Ni Catalytic Hydrogenation

Page: [191 - 193] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

Nabumetone is efficiently and economically prepared from hydrogenation of 3-methoxycarbonyl-4-(6- methoxy-2-naphthyl) but-3-en-2-one catalyzed by Raney Ni (W-2) under 145.0 psi H2 at 45 C and subsequent acid hydrolysis in 88.1% yield and 99% purity (GC). A high vacuum distillation or rectification purification method is used to improve the whole qualification of nabumetone.