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Letters in Organic Chemistry

Author(s): Laurent Brard, Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson and Nicholi Vorsa

DOI: 10.2174/157017808783743966

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Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines

Page: [103 - 109] Pages: 7

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Abstract

The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.

Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer